President Barack Obama is not yet on the Top 10 Unfortunate Political One-Liners list. Democrat Bill Clinton is on it twice, Republican George W Bush is not even on it, and Republican Richard Nixon leads with the worst line.
Hopefully, Obama will remain off the list. He will say stupid things. How he responds is key. He has yet to show the quick humor of Ronald Reagan, and comes across very serious. He'll need to quickly say, "Oops," and move on.
While George W Bush was not a polished speaker like Obama, his challenges were slight - the wrong word, or poor pronunciation. With Clinton and Nixon, it was about lying.